She was the head writer for The Ellen DeGeneres Show and occasionally appears on screen in sketches and other segments. She was also part of a comic duo (with Mary Lynn Rajskub) called Girls Guitar Club.
Kilgariff served as the head writer for The Rosie Show which aired on the Oprah Winfrey Network. She later served as the head writer for The Pete Holmes Show which aired on TBS.
Today, she's found a niche for herself as the composer of scathingly funny songs about smart-phone obsession, drinking on holidays and dysfunctional relationships.